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The Chronic Crohns Campaign UK. ( TCCC.UK ).

The Chronic Crohns Campaign UK - Why We Are Here !!!

TCCC.UK & TNHC.UK Campaign Literature.

The Chronic Crohns Campaign UK - Other TCCC.UK Contacts

TCCC.UK - Funds To Kings College London.

TCCC.UK - Action Medical Research details.........

TCCC.UK Campaign News ,Updates and Success !!!

The Chronic Crohns Campaign UK- The Breaking News.

TCCC.UK &The 3 Natural Alternatives In Sarah's Story

The New DNA Crohns Vaccine @ Kings College London.

TCCC.UK & Aloe Vera - Nature's Silent Healer. Books

TCCC.UK Raising Awareness - Press Coverage 1996 to 2006.

TCCC.UK MAP More Breaking News !!!!!!!!!!!!!!!!!!!!!!

Sarah's Crohns Success Story From 1989 to 2006.

Sarah's Crohns Success Story From 2001 to 2006.

Over 90 Degrees Still Does Not Kill Map Bacteria In Milk.

Tim Page - My Side Of The Story In All This Campaigning.

How To Order Aloe Vera, As We Do, At A Lower Price In The UK.

How To Get A Glyconutrient Powder Here In The UK

"Give Us A Quid Or Two" -The DNA Crohns Vaccine Appeal

PARA'S Medical Advisory Council

PARA'S Scientific Advisory Council.

A Message To Internet Hackers / Spammers !!

In Loving Memory Of Hadge Elliott 1956 To 2005.

The New DNA CrohnsVaccine Summary 2006.

TCCC.UK Consultation with DEFRA in 2002 & 2004.

The Chronic Crohns Campaign UK Press Info 1996 to 2006.

The Orkney Islands Crohns & U.C. N A C Group

Glyconutrients - What Are They ?

More On Glyconutrients - The 8 Sugars That Heal.....

Birmingham Contact For TCCC.UK - Stuart Morris IIHHT ICHT dip

MMR = Crohns or Autism ?

How To Get Aloe Vera & Other Aloe Vera Items Outside UK.

Other People'sTestimonials.........

Crohns & Contraception.

More On MAP - The 2 AntibioticsTreatment By Prof JHT.

Other Interesting Natural Health Documents.

More On The Bacteria MAP - 2

Scottish News On Crohns

More On Fluoride

TCCC.UK & The BBC

Baby Milk - The FSA Update December 2006.

Prof John Hermon Taylor's New Update In March 2008.

Christmas 2007 & New Year 2008.

Crohns Sufferers - Some National Figures @ 2006

Crohns Disease By Eye Online

Intracellular Pathogen Group/St George's University London.

The Italian Crohns Campaign Connections.

Dr Ira Shafron M.D

About PARA

TCCC.UK Photos.

For Jewellery Findings & Supplies In Tunbridge Wells, Kent.

A Friendly Ileostomy Councillor For Contact & Advice.

A Memorial Page To My Grandad Who Inspired Me.

Crohns & Food Intolerances & Illness.

TCCC.UK Petition To The UK Prime Minister + Another Petition

DrugWatch Check Them Out...

Crohns Research or IBD or IBS Stories In The News

Prof John Hermon -Taylor On You Tube & TV 2008..

Support Our New DNA Crohns Vaccine Fundraisers.

Further Water And Milk Press Coverage.

Can MAP Cause Ulcerated Colitis, As It Does Crohns..

TCCC.UK - Why We Are Here In 2008, To Help & Advise You.

TCCC.UK - Announcements In 2008.

Useful Addresses For Complaints On The NHS.

Hannah's Story - from 2006 to 2008....Ongoing.

Prof John Hermon -Taylor Updates In 2008.

Scientific Papers On IBDs.

New Book of Tim Page Crusader.

Need A Good Crohns Doctor ?

Contact Information for The Chronic Crohns Campaign UK

Links for The Chronic Crohns Campaign UK

Message Board

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Event Calendar

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Give Us A Quid Or Two - The New DNA Crohns Vaccine Appeal.

Prof. John Hermon-Taylor & Tim Page & TCCC.UK.

Please If You Can Help Us.......

" Give Us A Quid Or Two " - Ł700.000 Appeal -

@ December 19th 2005.

" Give Us A Quid Or Two " - Ł550.000 Appeal -

@ December 19th 2006.

" Give Us A Quid Or Two " - Ł 530.000 Appeal -

@ MAY 1st 2007.
" Give Us A Quid or Two " - Ł 479.900 Appeal -
Now Due To Revaluation Of Future Costs.

@ March 2008.
" Give Us A Quid or Two " - Ł 600.000 Appeal -

This is a newish Campaign drive to Raise the final funds for getting The New DNA Crohns Vaccine through the red tape & licensing, that is required with all new vaccines.

The New DNA Crohns Vaccine is Now " Formulated " to Human Strength. This is a Major Step foward in the development in this New DNA Crohns Vaccine.

Please, if you suffer with Crohns, or you have a friend or relative and you would like to help us achieve this goal in getting this New DNA Crohns Vaccine through it's last final stage, please send a donation of Ł1 or Ł2 or more to : -

As From The 12th March 2008.

Professor John Hermon-Taylor,
Division of Nutritional Sciences,
School of Biomedical and Health Sciences,
Franklin-Wilkins Building, Kings College London,
Stamford Street, London, SE1 9NH. United Kingdom.
Tel : + 44 (0) 207 848 4552.

Email: j.hermon@kcl.ac.uk
The new vaccine fund at King's is coded JQA1036.
Donor cheques ( with very sincere thanks from me ) should be made payable to : -

"King's College London"
with JQA1036 written on the back. THANKYOU.

WITH MANY THANKS FOR YOUR HELP.

CROHNS

A modern therapeutic vaccine to treat people suffering from Crohn’s disease is ready to proceed to clinical trials in humans. Please help us with funding needed Ł400.000.

CHEQUES payable to : -

" Kings College London "

On Back of cheque please

CROHNS VACCINE A/C No : JQA 1036

For further information

CONTACT : -

Professor John Hermon-Taylor

jhermon@kcl.ac.uk

Exempt Charity - Tax Ref: X66491.

Please make cheques payable to "Kings College London" with Crohns Vaccine A/C No : JQA 1036 written on the back, and mailed direct to Prof.John Hermon-Taylor (contact details above).

All Funds Go Only For The New DNA Crohns Vaccine.

Gift Aid Certificates Are Available.

I would like to thank all those that have donated to the creation of this New DNA Crohns Vaccine, and hope your further generosity will enable us to the completion of what has been a massive challenge, especially for the Professor, his team & my Campaign team. We have all come so far, and this really is the final stage for us in conquering this horrendous illness.( please see further update, now below ) It would then leave it to a vaccine manufacturing company, to produce the vaccine, for all Crohns sufferers around the World..Tim Page.

contact Tim Page on : tccc.uk@btinternet.com

If you need any help or advice for yourself, friend or family
member with Crohns or other IBD, please do contact me, I am here to help you.

January 2006.

Further Updates : - Further Updates : - Further Updates : -

The Prof, John Hermon Taylor & his team of scientists have decided to manufacture the New DNA Crohns Vaccine @ Kings College, London, after the redtape, testing & licensing.

The cost to do this ontop of the redtape, testing & licensing that will cost Ł700.000, ( Ł600.000 to go now ) the cost will be Ł1.5 Million to manufacture the new vaccine. By keeping this inhouse it will keep the costs down also per crohns sufferer, making it more available. Please support us, this really is the final step to producing & manufacturing this New DNA Crohns Vaccine. We have raised huge sums of money to get this far, and need this to complete this Crohns challenge, for all those suffering this horrendous illness...............Tim Page.

Update In MAY 2007.

Ł 530.000 To Go For Us All, To Get To Manufacture Stage.

Update In March 2008.
Due To Revaluation Of Future Costs.

Ł 600.000 To Go For Us All, To Get To Manufacture Stage.

Ł1.8 Million Raised To Get This Far In Over 12 Years.

Ł1.5 Million To Actually Manufacture The Vaccine.

Please See Prof John Hermon-Taylor's December Update :

Lower Down This Website Menu, Thanks.

St George's University of London Link Here : -
St George's University of London.

The New DNA Crohns Vaccine From Prof John Hermon -Taylor

Prof John Hermon-Taylor.

A MODERN VACCINE TO TREAT CROHN’S DISEASE.

Crohn’s disease began in the developed economies of Western Europe and North America about the middle third of the 20th century. Thereafter with plateaus at intervals in some regions it has steadily increased in frequency. The latest information available from Europe shows the disease climbing at about 25% overall in the last 10 years. A similar rise has taken place in North America. The region worst hit is Nova Scotia where 1 in 300 people are now affected. Crohn’s disease is spreading worldwide so that it is rising in countries which were formerly thought to be free of the disease. The results of epidemiological research from Stockholm and the Czech Republic as well as from Melbourne at the opposite end of the planet, show that the reported increase in Crohn’s disease in children in those areas over recent years has averaged about 5 fold per decade.

For an individual person with Crohn’s disease the mainstay of treatment is suppression of the immune system with drugs like Prednisolone and azathioprine. Ordinary antibiotics can help. In people with acute flares the newer agent Infliximab usually brings about remission. These treatments work by suppressing the inflammation not by treating the cause of the Crohn’s disease so that although the relief they may bring is welcome, relapse is almost inevitable. Research groups in the UK and the Netherlands analysing the world medical literature have found that there has been no statistically significant improvement in the major long-term outcomes in Crohn’s disease, like drug dependency or the need for major surgery, over the last 35 years.

From the large picture as well as for individual Crohn’s disease sufferers themselves and their families, the conventional strategy of focussing research and treatment almost exclusively on identifying and suppressing disease mechanisms rather than on disease causation is not winning against Crohn’s disease, it is losing. A radical change in strategy directing treatment at the cause of the disease is essential. Our research over more than 15 years, which has recently been confirmed by other scientific researchers in Europe and North America, has placed this issue centre stage.

Reliable scientific evidence strongly suggests that most of Crohn’s disease is being caused by a bug called MAP…short for Mycobacterium avium subspecies paratuberculosis. MAP is a proven cause of chronic inflammation of the intestine of different types affecting a wide range of animal species including primates. MAP infection is widespread in domestic livestock and there are wildlife reservoirs. MAP is being transmitted to people in milk supplies as well as from environmental sources such as contaminated waters. MAP is very difficult to detect in humans but when the tests are done correctly almost everybody with Crohn’s disease is found to be infected. To put it another way…..almost everybody suffering from chronic inflammation of the intestine (of the Crohn’s disease type)….is infected with a scientifically well characterized multi-host pathogen which has the proven specific ability to cause chronic inflammation of the intestine.

From 1992 I developed anti-MAP treatment using a combination of the antibiotics rifabutin and clarithromycin to which MAP is partially sensitive. The lives of a substantial proportion of people struggling with serious Crohn’s disease have been turned around by this treatment and many have been rescued from major surgery. But MAP infections are very difficult to eradicate and this treatment does not always work. Not everyone responds, and relapses although often mild and containable, do occur. We need new anti-MAP treatments.
Conventional vaccines work by stimulating antibodies in the blood which bind to an incoming bug and prevent people getting sick…hepatitis or pneumonia for example. But conventional preventative vaccines could not get at the MAP bugs in Crohn’s disease because the MAP bugs are already hiding inside cells. However, modern vaccines use DNA technologies to arm-up populations of hunter-killer immune ‘T’ cells. These patrol the body and kill MAP-infected cells together with the MAP they contain. Deleted cells are replaced with healthy ones. So modern vaccines can be used to treat chronic disease. There is already evidence that they may work in TB which is also caused by a member of the mycobacterium family.

We began work on the anti-MAP vaccine in 2001. We knew that the disease-causing properties of MAP lay in only 5% of its DNA genome. So we used modern bioinformatics and computer programs to focus on this 5% and pick 4 key bits of the MAP bug. Two of these bits sit on the MAP surface and two are released from the bug, so all 4 are ‘seen’ by the immune system of someone with Crohn’s disease.

MAP DNA speaks a slightly different ‘language’ to human DNA. So over 2002-2003 we synthesised our 4 MAP genes in human DNA-speak and strung them together in a single cassette. In 2003-2004 we inserted this MAP-cassette into 2 harmless carrier viruses called MVA and Ad5 already approved for clinical trial use in TB, malaria and in some cancer vaccines. We showed that the MAP-cassette inserts in MVA and Ad5 were stable and worked nicely. Vaccination of mice with Ad5 to prime and MVA to boost produced huge numbers of anti-MAP hunter-killer cells. There were no side effects and all the mice remained quite healthy.

In 2004 - 2005 we tested the vaccination procedure in mice infected with a laboratory strain of MAP. Six months after infection with MAP, sham vaccinated mice had 100-10,000 MAP bugs per gram in their spleens. In the mice which got the real vaccine we could not detect the MAP bug at all in ľ of them and the bugs were at the lowest limit of detection by a very sensitive DNA test in the others. Mice which had been vaccinated before exposure to MAP infection were also partially protected. Again, none of the mice showed side effects from the vaccine. We have since repeated these studies against a virulent recent disease isolate of MAP and the successful results were confirmed.

The modern anti-MAP vaccine we have produced is highly effective in treating MAP infection and offers protection against re-infection. Although further laboratory work is currently in progress we are now in a position to begin the rigorous application process for regulatory and ethical approvals for clinical trials in people. The first step is to get the vaccine made under contract according to Good Manufacturing Practice (GMP) and put through rigorous toxicity testing. The total cost of getting the vaccine into human clinical trials is UK Ł700.000. ( now Ł600.000 ).

We need your help….....can you help us please ?

Please make cheques payable to "Kings College London" with Crohns Vaccine A/C No : JQA 1036 written on the back, and mailed direct to Prof. Hermon-Taylor (contact details above).

All FUNDS go only for the NEW DNA CROHNS VACCINE.

Gift Aid Certificates available.

All the scientific indicators so far say that the vaccine treatment will work. If this is borne out in the human clinical trials we shall at last have a totally new and potentially lasting treatment to offer people with Crohn’s disease.

Issued By Prof JHT to Tim Page - TCCC.UK.

As At October 2006 - Update To Follow Shortly From Prof JHT. Now to be found lower down in menu on this site.

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